Depression is common in patients with dementia and antidepressants are widely prescribed for this population although the evidence remains limited. This randomised controlled trial conducted by researchers at the Institute of Psychiatry in London and published in the Lancet, explored the safety and efficacy of two widely-used drugs (sertraline and mirtazapine) in patients with dementia and [read the full story…]
Older people who suffer from depression and executive dysfunction experience significant levels of disability and often don’t respond well to conventional drug treatments. This randomised controlled trial conducted by researchers from Weill Cornell Medical College in New York State, attempted to find out if problem-solving therapy is better than supportive therapy for reducing disability in older [read the full story…]
This cohort study conducted by researchers from the St. Louis Veterans Affairs Medical Center set out to answer the question: Are antidepressants associated with an increased or decreased risk of incident myocardial infarction and all-cause mortality? 93,653 patients aged 25–80 years (average age 51.5 years, 14.1% female, 77.8% White, 57.1% not married) were identified using the [read the full story…]
The objective of this cost-utility analysis was to assess the cost-effectiveness of providing group cognitive-behavioural therapy (CBT), compared with routine primary care, for women with postnatal depression in the UK. Group CBT was compared with routine primary care for women with postnatal depression, defined by their Edinburgh Postnatal Depression Scale (EPDS) score, with scores ranging [read the full story…]
It has long been documented that there are clinical differences between depression and bipolar disorder, but to date there has been no reliable study that shows differences in structural brain abnormalities in the two disorders. A research team from the Institute of Psychiatry in London have published a meta analysis that investigates structural brain changes in [read the full story…]
There are increasing levels of interest in stepped care models to treat mental health problems in primary care. This randomised controlled trial investigated the effectiveness of a stepped care programme for treating depression and anxiety in 120 adults (aged 18-65 years with minor or major DSM-IV depressive and/or anxiety disorders) in general practice. Patients were [read the full story…]
The hormone oestrogen could play an important role in late-life depression, according to new research published in the August issue of the British Journal of Psychiatry. Oestrogen is best known as one of the significant hormones in reproduction. It is also believed to have a part to play in mood and mental health, because of [read the full story…]
Music therapy, when combined with standard treatment, is effective in helping people with depression, according to a small Finnish randomised controlled trial published in the August issue of the British Journal of Psychiatry. The research team from the University of Jyväskylä, led by Professor Jaakko Erkkilä and Professor Christian Gold, recruited 79 people aged between [read the full story…]
The manufacturer of agomelatine (Servier) has informed NICE that it would not be making an evidence submission for the appraisal of agomelatine for the treatment of major depressive episodes. Servier drew attention to the fact that NICE guidelines for England and Wales recommend generic selective serotonin reuptake inhibitors (SSRIs) as first-line treatment followed by a [read the full story…]
Treating depression is rarely straightforward, but treating someone who is depressed and also has comorbid personality disorders can be even more complicated. Studies have shown that short-term psychodynamic psychotherapy (STPP) is a treatment worth considering for depression and personality disorders when they occur individually, but this intervention has not yet been studied systematically for people [read the full story…]
