Non-surgical periodontal treatment – is there a role for systemic antibiotics?


This review update includes 23 new studies comparing the effects of antibiotic therapy adjunctive to scaling and root planning for periodontal disease. While some additional benefit was shown the authors could not establish definitive conclusions and guidelines regarding their use.

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Review finds only a small benefit from antibiotic use in patients with acute sinusitis


Sinusitis is one of the commonest reasons for visiting the doctor accounting for 15% to 21% of all adult outpatient antibiotic prescriptions. Patients may also present at dental practices, as pain from upper posterior teeth can be indistinguishable from sinusitis.  Typical signs and symptoms are purulent nasal discharge, postnasal drip, sinus pain at palpation, nasal [read the full story…]

Review suggests that antibiotics are beneficial for reducing failure of dental implants


With the increasing popularity of dental implants and the difficulties of managing infections around them it is important to know whether the use of prophylactic antibiotics is beneficial or not. This review is an update of a Cochrane review originally published in 2008 and last updated in 2010. The aim of the review was to [read the full story…]

ADA-EBD summary on amoxicillin/metronidazole therapy for aggressive periodontitis


This ADA-EBD critical summary looks at a systematic review from the same group that conducted the review that we highlighted yesterday (Sgolastra et al 2012).  This time the question was whether the use of amoxicillin/metronidazole (AMX/MET) as an adjunct to scaling and root planning (SRP) was more effective than SRP alone in the treatment of [read the full story…]

Small trial suggests no difference between chlorhexidine rinse and amoxicillin in reducing bacteraemia during third molar extractions

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As bacteraemia occurs during toothbrushing  (Dental Elf 5th Oct 2011) it is to be anticipated during more invasive activities such as flossing, scaling (Dental Elf 9th Jan 2013) and dental extractions.  The main aim of this study was to directly compare and determine the effect of a pre- procedure rinse of 0.12% chlorhexidine on the [read the full story…]

Latest critical summaries from the American Dental Association Center for Evidence-based Dentistry


Two new critical summaries are now available from the ADA-EBD website. First is a summary of a 2012 systematic review by Zandbergen et al that looked the systemic administration of amoxicillin and metronidazole as an adjunct to scaling and root planning (Dental Elf 25th May 2012). The review notes that there was no comparison in [read the full story…]

Trail shows improved outcomes with metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis


The main aim of this study was to evaluate the effects of the adjunctive use of metronidazole (MTZ) or MTZ + amoxicillin (AMX) in the treatment of generalized chronic periodontitis (ChP). Participants with untreated generalized ChP were randomised to receive either scaling and root planning (SRP) only (n= 40); SRP with MTZ, 400 mg/3 times [read the full story…]

Systemic antibiotics as an adjunct to non-surgical periodontal treatment


Systemic and locally delivered antibiotics have been used as an adjunct to scaling and root planing (SRP) for the treatment of periodontal disease for many years. The aim of this review was to systematically evaluate the data concerning the effect of the concomitant administration of amoxicillin and metronidazole adjunctive to SRP in otherwise healthy adults. [read the full story…]

Amoxycillin not helpful for acute sinusitis


Acute sinusitis (rhinosinusitis) is a common disease with 1 in 5 antibiotic prescriptions for adults in the United States being for sinusitis.  US Centers for Disease Control  and Prevention (CDC) guidelines recommend using clinical criteria for diagnosis and  reserving antibiotic treatment for patients with moderately severe or severe symptoms.  The aim of this study was [read the full story…]

Better outcomes with metronidazole and amoxicillin as an adjunct to full mouth disinfection for patients with aggressive periodontitis

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About 1 in 1000 susceptible patients suffers from aggressive periodontitis. Sufferers have more rapid  gingival attachment loss with some losing more that half their bony support by 35. This can be localised  to a small number of teeth or more generalised.  The aim of this study was to evaluate the adjunctive clinical and microbiological effects [read the full story…]