Systemic antibiotics for aggressive periodontitis?

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This review of systemic antibiotics and non-surgical periodontal therapy for aggressive periodontitis included 13 RCTs and suggests a statistically significant benefit compared to non-surgical therapy alone.

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Aggressive periodontitis: systemic antibiotics may improve outcome

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This review and network meta-analysis included 11 small RCTs of limited quality, suggesting a statistically significant benefit for the use of adjunctive systemic antibiotics for the treatment of aggressive periodontitis.

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Non-surgical periodontal treatment – is there a role for systemic antibiotics?

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This review update includes 23 new studies comparing the effects of antibiotic therapy adjunctive to scaling and root planning for periodontal disease. While some additional benefit was shown the authors could not establish definitive conclusions and guidelines regarding their use.

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Review finds only a small benefit from antibiotic use in patients with acute sinusitis

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Sinusitis is one of the commonest reasons for visiting the doctor accounting for 15% to 21% of all adult outpatient antibiotic prescriptions. Patients may also present at dental practices, as pain from upper posterior teeth can be indistinguishable from sinusitis.  Typical signs and symptoms are purulent nasal discharge, postnasal drip, sinus pain at palpation, nasal [read the full story…]

Review suggests that antibiotics are beneficial for reducing failure of dental implants

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With the increasing popularity of dental implants and the difficulties of managing infections around them it is important to know whether the use of prophylactic antibiotics is beneficial or not. This review is an update of a Cochrane review originally published in 2008 and last updated in 2010. The aim of the review was to [read the full story…]

ADA-EBD summary on amoxicillin/metronidazole therapy for aggressive periodontitis

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This ADA-EBD critical summary looks at a systematic review from the same group that conducted the review that we highlighted yesterday (Sgolastra et al 2012).  This time the question was whether the use of amoxicillin/metronidazole (AMX/MET) as an adjunct to scaling and root planning (SRP) was more effective than SRP alone in the treatment of [read the full story…]

Small trial suggests no difference between chlorhexidine rinse and amoxicillin in reducing bacteraemia during third molar extractions

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As bacteraemia occurs during toothbrushing  (Dental Elf 5th Oct 2011) it is to be anticipated during more invasive activities such as flossing, scaling (Dental Elf 9th Jan 2013) and dental extractions.  The main aim of this study was to directly compare and determine the effect of a pre- procedure rinse of 0.12% chlorhexidine on the [read the full story…]

Latest critical summaries from the American Dental Association Center for Evidence-based Dentistry

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Two new critical summaries are now available from the ADA-EBD website. First is a summary of a 2012 systematic review by Zandbergen et al that looked the systemic administration of amoxicillin and metronidazole as an adjunct to scaling and root planning (Dental Elf 25th May 2012). The review notes that there was no comparison in [read the full story…]

Trail shows improved outcomes with metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis

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The main aim of this study was to evaluate the effects of the adjunctive use of metronidazole (MTZ) or MTZ + amoxicillin (AMX) in the treatment of generalized chronic periodontitis (ChP). Participants with untreated generalized ChP were randomised to receive either scaling and root planning (SRP) only (n= 40); SRP with MTZ, 400 mg/3 times [read the full story…]

Systemic antibiotics as an adjunct to non-surgical periodontal treatment

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Systemic and locally delivered antibiotics have been used as an adjunct to scaling and root planing (SRP) for the treatment of periodontal disease for many years. The aim of this review was to systematically evaluate the data concerning the effect of the concomitant administration of amoxicillin and metronidazole adjunctive to SRP in otherwise healthy adults. [read the full story…]