Cochrane review says there’s insufficient evidence to tell whether fluoxetine is better or worse than other treatments for depression

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Depression is common in primary care and associated with a substantial personal, social and societal burden. There is considerable ongoing controversy regarding whether antidepressant pharmacotherapy works and, in particular, for whom. One widely-prescribed antidepressant is fluoxetine (Prozac), an antidepressant of the selective serotonin reuptake inhibitors (SSRI) class. Although a number of more recent antidepressants are [read the full story…]

Primary care interventions for alcohol misuse: US Preventative Services Task Force recommendations

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Alcohol misuse is recognised as one of the major health care issues in the US. Specifically, alcohol misuse is ranked third in causes of preventable deaths (after tobacco and obesity) affecting 30% of the population. Alcohol dependence has 4% prevalence in the US, but hazardous drinking patterns are believed to be evident in 21% of [read the full story…]

Study suggests link between depression, antidepressants and antibiotic-related clostridium difficile infection

Washing hands

Hospitals are supposed to make people better, not worse – so hospital-acquired infections are always a big topic. Clostridium difficile infection (CDI) is the most commonly diagnosed cause of antibiotic-associated diarrhoea, and causes more than 7,000 deaths each year in the US alone. There have been studies into risk factors for CDI, one of them [read the full story…]

Cognitive dissonance and positive health behaviours: a systematic review shows dissonance-based interventions can be successful

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Most of us have heard of cognitive dissonance although the term is often used incorrectly. I’m sure when you find out you thought you were using it correctly but weren’t, you’ll feel bad. Cognitive dissonance refers to a state of psychological discomfort that arises from conflicting attitudes or beliefs. For example you may have a [read the full story…]

Using adaptive treatments for smoking cessation may prove effective

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Around 20% of adults in the UK smoke cigarettes regularly. Smoking was the primary cause of approximately 462,900 hospital admissions and 79,100 (18%) deaths in adults over the age of 35 last year. Therefore, smoking cessation represents a serious (and costly!) clinical challenge on an individual and global level. Many smoking cessation aids are available, [read the full story…]

What sort of therapy helps children affected by sexual abuse? New Cochrane Review finds that more research is needed

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Childhood sexual abuse has a devastating impact on many of the children and adolescents who are affected by it. It is a significant problem worldwide and has the potential to have serious negative impacts on mental health and physical health. Experiencing childhood sexual abuse often has negative impacts on the individual’s ability to function socially, [read the full story…]

Concurrent treatments may be effective in treating comorbid alcohol dependence and PTSD

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In those with post-traumatic stress disorder (PTSD), alcohol abuse or dependence is the most common co-morbid disorder. Unfortunately, although individuals with PTSD and alcohol dependence (AD) often have complex needs, the treatments available usually only target one issue. This is often due to specialist treatment services not having access to treatments for comorbid disorders, and [read the full story…]

Systematic review of dropout rates from clinical trials of methylphenidate for adult ADHD

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Attention deficit hyperactivity disorder (ADHD) is characterised by inattention, excessive activity levels and impulsive behaviours. Although it is an early developmental condition and is associated with childhood, in many instances, it is a lifelong condition. ADHD in adulthood is increasingly being recognised. Clinical guidelines and research suggest that the stimulant drug methylphenidate can reduce ADHD [read the full story…]

Latest evidence from NICE on Obsessive Compulsive Disorder (OCD) and Body Dysmorphic Disorder (BDD)

Many of the drug treatments included in this report are not currently approved for use in the UK

Obsessive compulsive disorder (OCD) is a condition that has recently been given a significant amount of TV airplay and media coverage, perhaps most notably in the Channel 4 documentary Jon Richardson: A little bit OCD, which received mostly good reviews from mental health groups. Despite this reasonable public profile, our knowledge about the best way [read the full story…]

Women who experience domestic violence are almost twice as likely to suffer from depression and vice versa

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In June this year The World Health Organisation (WHO) published a report, which highlighted violence against women as a ‘global health problem of epidemic proportions’. The report detailed the impact of violence on the physical and mental health of women and girls. This can range from broken bones to pregnancy-related complications, mental problems and impaired [read the full story…]