Valproate is widely used as a mood stabiliser for people with bipolar disorder, despite the fact that there is very little evidence that shows the effectiveness of this treatment. This observational cohort study looked at over 4,000 bipolar patients in Denmark who were treated with lithium or valproate from 1995 to 2006. The results favoured [read the full story…]
The Cochrane Scizophrenia Group have updated the systematic review that brings together all randomised controlled trials (RCTs) designed to prevent progression to psychosis in people showing prodromal symptoms, or to improve outcome for people with first-episode psychosis. The reviewers found 18 RCTs this time around, but (as is often the case with systematic reviews) the [read the full story…]
Regular physical activity is a cornerstone of good health and previous studies have shown that many people with learning disabilities do not engage in such activity. This systematic review set out to critically assess the evidence on the effectiveness of physical activity interventions for adults with learning disabilities. The authors found eleven clinical studies that [read the full story…]
This cohort study conducted by the Intensive Medicines Monitoring Programme (IMMP) in New Zealand, set out to determine more accurately the rates of nocturnal enuresis in patients on clozapine and other atypical antipsychotics (olanzapine, quetiapine and risperidone). Prescription data for clozapine, olanzapine, risperidone and quetiapine were returned from pharmacies throughout New Zealand directly to the [read the full story…]
This small randomised controlled trial conducted in Pittsburgh set out to compare community-provided trauma-focused cognitive behavior therapy (TF-CBT) with usual community treatment for children with intimate partner violence (IPV)-related posttraumatic stress disorder (PTSD) symptoms. The trial randomised 124 children (7-14 year olds) to receive 8 sessions of TF-CBT or usual care (child-centered therapy). A number of [read the full story…]
People with schizophrenia are sometimes prescribed multiple antipsychotic drugs, even though clinical guidelines rarely recommend this course of action. This cross-sectional observational study from Denmark explored the reasons behind this prescribing practice in two treatment centres; one that had high rates of antipsychotic polypharmacy and the other that had low rates. The researchers sent a [read the full story…]
The Dementia Action Alliance has launched a call to action on the use of antipsychotic drugs for people with dementia: All people with dementia who are receiving antipsychotic drugs should receive a clinical review from their doctor to ensure that their care is compliant with current best practice and guidelines and that alternatives to medication have been [read the full story…]
People with learning disabilities with schizophrenia and related psychoses have been found to be more likely to be treatment resistant than those without learning disabilities. This paper describes a case study which highlights many of the issues faced when carrying out assessments and developing management plans for such individuals. The authors point out that Clozapine, [read the full story…]
This audit of clinical practice in a mental health service for people with learning disabilities looked at the current approach to people with learning disabilities and psychotic disorders. The researchers looked at clinical practice with 910 people who were patients of the learning disability psychiatrists in Buckinghamshire. The current approach to clinical practice in the [read the full story…]
A randomised controlled trial published in the Archives of General Psychiatry has found that problem-solving therapy is a useful treatment alternative for elderly people with depression and executive dysfunction who do not respond well to conventional drug treatments. The trial randomised 221 patients to either problem-solving therapy (PST) or supportive therapy (ST) and followed them [read the full story…]
