No well-designed studies of topical agents for treatment of HIV-related oral ulcers

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Oral Ulcers occur more frequently, last longer and produce more painful symptoms in HIV-infected adults. Aphthous ulcers are generally classified as major, minor or herpetiform. Major ulcers can exceed 3cm in diameter and can develop into large necrotic lesions. Major ulcers are seen more commonly in HIV-infected than non-infected adults.  The aim of this Cochrane [read the full story…]

No strong evidence for any topical treatments for relieving the symptoms of dry mouth

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The subjective sensation of dry mouth or xerostomia is a common symptom and estimates of the prevalence vary from 10-50%.  The Cochrane Collaboration published systematic  of topical treatments for reducing the effects of dry mouth in 2011(Furness et al). Recently the American Dental Association’s Evidence-based Dentistry Center have published a critical summary of this review [read the full story…]

Robust studies needed to evaluate topical agents available to treat HIV related oral ulcers

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HIV/AIDS is currently the leading cause of death in adults in Africa and the sixth leading cause of death worldwide. In HIV infected adults, oral ulcers occur more frequently, last longer, and produce more painful symptoms than in immunocompetent people.  The aim of this review was to evaluate the efficacy and side effects of topical [read the full story…]

No strong evidence that any topical treatment is effective for relieving the sensation of dry mouth

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The prevalence of persistent dry mouth varies but a conservative estimates is that about 20% in the general population, with increased prevalence in women (up to 30%) and in the elderly (up to 50%). The aim of this Cochrane review was to determine which topical treatments for dry mouth are effective in reducing this symptom. [read the full story…]