Trail shows improved outcomes with metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis

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The main aim of this study was to evaluate the effects of the adjunctive use of metronidazole (MTZ) or MTZ + amoxicillin (AMX) in the treatment of generalized chronic periodontitis (ChP). Participants with untreated generalized ChP were randomised to receive either scaling and root planning (SRP) only (n= 40); SRP with MTZ, 400 mg/3 times [read the full story…]

Systemic antibiotics as an adjunct to non-surgical periodontal treatment

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Systemic and locally delivered antibiotics have been used as an adjunct to scaling and root planing (SRP) for the treatment of periodontal disease for many years. The aim of this review was to systematically evaluate the data concerning the effect of the concomitant administration of amoxicillin and metronidazole adjunctive to SRP in otherwise healthy adults. [read the full story…]

Better outcomes with metronidazole and amoxicillin as an adjunct to full mouth disinfection for patients with aggressive periodontitis

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About 1 in 1000 susceptible patients suffers from aggressive periodontitis. Sufferers have more rapid  gingival attachment loss with some losing more that half their bony support by 35. This can be localised  to a small number of teeth or more generalised.  The aim of this study was to evaluate the adjunctive clinical and microbiological effects [read the full story…]

Some evidence to support adjunctive amoxicillin and metronidazole for treatment of chronic periodontitis

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Chronic periodontitis affects between 5-20% of the population. Scaling and root planing (SRP) is one of the most effective methods of treatment. The aim of this review was to assess whether  the adjunct of amoxicillin and metronidazole (AMX/MET) to SRP increased its effectiveness compared to SRP alone. The authors searched eight databases and hand-searched a [read the full story…]