Can experiencing mental illness literally cause heartache?

feat

A systematic review of 22 million people finds several mental health conditions, including PTSD, depression and anxiety, are linked to higher acute coronary syndrome risk.

[read the full story...]

Approach Bias Modification for smoking cessation: NHS contender or game over?

feat

Approach Bias Modification didn’t significantly beat standard smoking cessation care, but this may say more about the trial’s power than the intervention itself.

[read the full story...]

Is atypical depression a clinically and genetically distinct subtype?

feat

A large Australian study suggests that atypical depression is genetically, metabolically and clinically distinct, with poorer response to SSRIs and SNRIs.

[read the full story...]

Psilocybin-assisted therapy for difficult-to-treat depression: underwhelming, but still vital?

feat

The EPISODE trial of psychedelic-assisted therapy for ‘treatment-resistant depression’ finds only modest effects, with a few clear responders, but lingering methodological questions.

[read the full story...]

Brain scans, depression, and AI: small signals, big questions

feat

A new study uses AI on brain scans to predict depression. The findings are modest, but the implications go beyond the hospital.

[read the full story...]

How sleep changes across later life, and what it means for mental health

feat

A large UK Biobank study tracked sleep in over 77,000 adults. Here’s what the data reveals about age, sex and mood.

[read the full story...]

MDMA-assisted therapy for depression: a promising but early first step

feat

A small proof-of-principle trial suggests MDMA-assisted therapy may be feasible and effective for depression, but open-label design and a highly pre-treated sample urge caution.

[read the full story...]

In the Land of the Unblind: are psychedelics really better than antidepressants?

feat

Psychedelic therapy looks impressive in trials, but when you account for the placebo effect, how does it really compare to antidepressants?

[read the full story...]

Can we predict and prevent weight gain in early psychosis?

Background,Of,Paper,Calendar,Page

New research suggests that weight gained in the first 12 weeks of antipsychotic treatment is the biggest driver of long-term obesity in psychosis.

[read the full story...]

Can positive expectations tune the immune system?

feat

Can training your brain’s reward circuits strengthen your immune response to vaccination? A new randomised controlled trial offers some fascinating early clues.

[read the full story...]