Small trial suggests limited short-term benefit from 0.1% pilocarpine mouthwash for xerostomia

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Xerostomia is a subjective sensation of dry mouth, this is a common symptom particularly in older adults and has a variety of causes. Pilocarpine is a cholinergic agonist that non-selectively binds to muscarinic receptors in smooth muscles in the gastrointestinal, urinary and pulmonary systems and stimulates the production of secretions from the salivary and sweat [read the full story…]

Insufficient evidence for effects of non-pharmacological interventions for the relief of dry mouth

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It has been estimated that between 10-26% of men and 10-33% of women experience dry mouth. The subjective sensation of dry mouth is called xerostomia and can be found in people with normal salivary gland function. The normal range of salivary production ranges from 0.5 to 1.5 litres per day.  The aim of this Cochrane [read the full story…]

No strong evidence for any topical treatments for relieving the symptoms of dry mouth

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The subjective sensation of dry mouth or xerostomia is a common symptom and estimates of the prevalence vary from 10-50%.  The Cochrane Collaboration published systematic  of topical treatments for reducing the effects of dry mouth in 2011(Furness et al). Recently the American Dental Association’s Evidence-based Dentistry Center have published a critical summary of this review [read the full story…]

New Cochrane Protocols February 2012

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The February issue of the Cochrane Library sees the publication of two new oral health protocols. It will be a little while before the reviews are published. However people for are working in these areas may be interested to know that these reviews are underway. The full text of each protocol is available from the [read the full story…]

No strong evidence that any topical treatment is effective for relieving the sensation of dry mouth

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The prevalence of persistent dry mouth varies but a conservative estimates is that about 20% in the general population, with increased prevalence in women (up to 30%) and in the elderly (up to 50%). The aim of this Cochrane review was to determine which topical treatments for dry mouth are effective in reducing this symptom. [read the full story…]