This review evaluating the preventive effect of regular applications of fluoride varnish (FV) on the development of white spot lesions (WSL) during orthodontic treatment included 7 RCTs. Meta-analyses demonstrated a reduction in the risk of WSL with regular FV applications but the certainty of evidence was very low.
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This review of the caries preventive effectiveness of topical fluorides in the primary dentition included 24 RCTs with 10 RCTs contributing to a network meta-analysis (NMA). While the NMA did allow a ranking of effectiveness the number of studies involved was small and 17 of the 24 studies were considered to be at high risk of bias.
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