Is atypical depression a clinically and genetically distinct subtype?

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A large Australian study suggests that atypical depression is genetically, metabolically and clinically distinct, with poorer response to SSRIs and SNRIs.

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Changing sleep patterns linked to cognitive decline and dementia

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Two large cohorts (one UK, one Chinese) found shifting from optimal to non-optimal sleep or stopping napping linked to higher dementia risk. But reverse causation limits certainty about prevention.

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What’s the matter? The role of white matter microstructure in depression-related cognitive decline

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Fionnuala Rogers discusses a study on the role of white matter microstructure in depression-related cognitive dysfunction, which highlights the importance of viewing major depressive disorder not only as a mood disorder, but as a condition with significant neurocognitive implications.

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