Genetic variation is a factor when treating schizophrenia with folate and vitamin B12 supplementation

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Symptoms associated with schizophrenia are often classified into two categories. The classical indicators such as hallucinations, delusions and thought disorder make up the ‘positive’ category whilst apathy and problems with concentration are ‘negative’ symptoms. These negative symptoms have previously been linked to decreased folate levels (Goff et al. 2004) and there is some evidence that [read the full story…]

Depression increases risk of all cause mortality (not just heart disease) in diabetes

Depression is associated with mortality of all causes

This blog is coming across the woodland in stereo as the Diabetes and Mental Elf join forces. In 2011 the Diabetes Elf highlighted Depression and Diabetes: a two way street? a systematic review looking at cause and effect of diabetes and depression and the link between diabetes and cardiovascular disease is not contested. However moving forward [read the full story…]

Foetal exposure to sodium valproate is linked with autism risk

Pregnant belly painting

The risks of congenital malformations and impact of cognitive development after foetal exposure to anti-epileptic drugs has been known for some time. Sodium valproate is a frequently used drug for epilepsy and other disorders (including bipolar disorder and migraine). The researchers aimed to examine the link between foetal exposure and subsequent development of autism. Methods [read the full story…]

NICE publish first clinical guideline on social anxiety disorder

Social humiliation

I wonder if the timing of this publication was planned to be so close to the release of DSM-5, but this debut guidance on social phobia (now known as social anxiety disorder) is certainly going to ruffle some feathers. It fuels the discussion about the medicalisation of human personality traits and some will see it [read the full story…]

Can functional brain imaging of social judgments shed light on the gender imbalance in autism spectrum disorder?

social cognition

It is well-documented that there are gender differences in mental health (see for example this Men’s Health Forum publication (PDF) about key mental health issues affecting men). In early development, boys are at a significantly higher risk than girls for meeting diagnostic criteria for autism spectrum disorder (ASD), as well as other developmental problems (e.g. developmental [read the full story…]

Methadone for opioid detoxification as effective as other medications, but all have high relapse rates

Heroin addiction

Dependence on opiates (a group of drugs including heroin, morphine, and methadone) can be highly destructive for both the individual and for the people around them. Heroin addiction in particular is associated with major health risks, co-morbid mental health problems, and a wide-range of social issues. Attempting to stop opiate use leads to severe withdrawal [read the full story…]

Study shows that adolescents with symptoms of depression and suicidality are more at risk of unhealthy romantic relationships in adulthood

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Clinical depression is unfortunately relatively common in adolescence with a prevalence of about 5%. The rates of suicide per 100,000 are around 12.0 for females and 14.2 for males aged 15-24 years with suicidality (thoughts or uncompleted attempts at suicide) likely to be higher. Research and clinical experience suggests issues relating to suicide and depression [read the full story…]

Anxiety is a common negative psychological outcome after stroke. How does this impact on the patient?

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Every year an estimated 152,000 people in the UK suffer a stroke (for more general information go to the Stroke Association website). Quality of life post stroke is not only influenced by physical impairment but also by psychological factors. Although anxiety disorders are the most common mental health problem globally, the study of anxiety post-stroke has [read the full story…]

Illegal drug use during pregnancy is associated with a host of complications for both Mother and baby

Mother and baby looking out window

The potential dangers of illegal drug use are never far from the media spotlight, and drug use during pregnancy may be associated with particular health problems both for the Mother and baby. Drug use during pregnancy has been linked with a number of negative outcomes, for example, cocaine use has been linked with an increased [read the full story…]

Childhood trauma and abuse is the smoking of psychiatry

Young girl cuddling teddy bear

Childhood trauma and abuse is the smoking of psychiatry. As a risk factor for mental illness it is comparable to how smoking a pack of cigarettes per day increases the risk of lung cancer and heart disease. As an adult psychiatrist I see the consequences of poor starts to life and do my best to [read the full story…]