Orthognathic surgery: intra-operative bleeding reduced with tranexamic acid

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This review looked at the efficacy of haemostatic adjuncts on intra-operative blood loss in orthognathic surgery. 11 RCTs were included and found that tranexamic acid reduced blood loss by about a third whether used topically or intravenously.

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Congenital bleeding disorders and dental extractions

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This Cochrane review looked at the effectiveness of haemostatic regimens for patients with bleeding disorders. Two small trials involving 59 patients demonstrated the efficacy of antifibrinolytic agents acid in people with bleeding disorders having dental extractions.

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Review shows that tranexamic acid reduced blood loss in orthognathic surgery

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Significant blood loss can occur during orthognathic surgery and there are risks associated with blood transfusion so minimizing blood loss during surgery is important.  A large number of trials and reviews have shown that the antifibrinolytic agent tranexamic acid ( a synthetic amino acid lysine analog )  can effectively reduce bleeding in a number of [read the full story…]

Tranexamic acid is effective in controlling blood loss in orthognathic surgery

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Conservation of blood is important in all forms of surgery and approximately 30% of patietns undergoing bimaxillary osteotomies require a transfusion. The aim of this trial was to assess the effect of tranexamic acid on blood loss, quality of surgical field and duration of surgery compared to the effect of nitroglycerin induced moderate hypotension alone [read the full story…]

Tranexamic acid in an irrigant fluid did not reduce blood loss during orthognathic surgery

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Choi  in a trial in 2009 found that an intravenous bolus administration of tranexamic acid at 20 mg/kg reduces blood loss compared with placebo during bimaxillary osteotomy.  The aim of this trial was to test whether the use of tranexamic acid in an irrigant fluid would decrease blood loss during orthognathic surgery Forty patients undergoing [read the full story…]