Long-acting injectable paliperidone palmitate for schizophrenia

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Tracey Roberts summarises a recent RCT of the efficacy and safety of paliperidone palmitate 3-month formulation for patients with schizophrenia.

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Pharmacotherapy for smoking cessation in severe mental illness

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Andrew Jones reports on a recent systematic review and network meta-analysis of the efficacy and tolerability of pharmacotherapy for smoking cessation in severe mental illness, which finds a promising but low quality result for bupropion and varenicline.

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Psychotropic medication in pregnancy: new evidence may help achieve a safe balance

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Joanne Wallace considers a recent health technology assessment on the risks and benefits of psychotropic medication in pregnancy, which supports previous associations between valproate and adverse child outcomes.

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Implementation intentions: helping people achieve their goals

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Alan Underwood highlights a new meta-analysis, which suggests that people with mental health problems can benefit if they are prompted to form if-then plans, which specify when, where and how they will achieve their goals.

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Antipsychotics for treatment-resistant schizophrenia

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Murtada Alsaif summarises a recent network meta-analysis, which looks at the efficacy, acceptability and tolerability of antipsychotics for treatment-resistant schizophrenia.

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Virtual reality as a treatment for persecutory delusions

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Suzanne Dash considers the findings of a promising new small randomised controlled trial, which aims to reduce delusional conviction in people with schizophrenia who experience persecutory delusions.

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Prognosis of brief psychotic episodes

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Samei Huda presents the findings of a new meta-analysis, which explores the prognostic significance of competing ways of defining and measuring brief psychotic episodes.

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What do you want from your psychiatric medication?

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John Baker presents a systematic review of preferences for medication-associated outcomes in mental disorders, which concludes that we just don’t know what value mental health service users place on the different outcomes that come from taking psychiatric medication.

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Crisis intervention for severe mental illness: Cochrane call for more evidence

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John Baker is struck by the lack of evidence for crisis intervention for people with severe mental illness, highlighted by a recently updated Cochrane systematic review.

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