Just how good are antipsychotics at preventing relapse? Bridging the efficacy-effectiveness gap

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Samei Huda summarises a new network meta-analysis in the Lancet Psychiatry on the efficacy and effectiveness of antipsychotics for schizophrenia in research settings, such as randomised controlled trials, versus real-world and clinical settings.

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Lived experience perspectives of acceptance and commitment therapy for people with psychosis

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Charlotte Huggett reflects on a qualitative study exploring the perspectives of people with psychosis receiving Acceptance and Commitment Therapy following a first episode of psychosis.

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Brain-body health please: new research supports integrated physical and mental health care

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Athina Aruldass finds that management of serious neuropsychiatric disorders should acknowledge the importance of poor physical health and target restoration of both brain and body function.

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Early intervention for psychosis: better outcomes in the short term?

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Emanuele Osimo blogs about the 20-year follow up of the OPUS trial, which tested early intervention services for people with first-episode schizophrenia spectrum disorder.

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‘Hearing Voices’ and self-help groups: hope and support for people who hear voices

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Lorna Collins reflects on a systematic review exploring the benefits of Hearing Voices and other self-help groups for people with auditory hallucinations.

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Neuroimaging abnormalities in first-episode psychosis: clinically-relevant or not?

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Joe Pierre considers a systematic review and meta-analysis on the prevalence of neuroimaging abnormalities in first-episode psychosis and the clinical relevance for service users presenting with first-episode psychosis.

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Predicting treatment-resistant psychosis using routine clinical measures

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Lorna Staines summarises a recent study on predicting treatment-resistant psychosis, which suggests that future risk prediction efforts should seek to consider routinely collected data.

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Clinical severity and instability as predictors for psychiatric hospitalisation: can one size fit all? 

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Florian Walter summarises a retrospective cohort study published in The Lancet Psychiatry that investigates whether early trajectories of clinical global impression severity can transdiagnostically predict later psychiatric hospitalisation.

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The healthcare cost of multimorbidity in people with mental health diagnoses in Denmark

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Kitty Saunders and Silke Vereeken explore the individual and population level healthcare costs of multimorbidities in people with at least one mental health diagnosis in Denmark.

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