This review and network meta-analysis of seven treatments for white spot lesions (WSLs) included 36 clinical RCTs published since 2007. The findings suggest that self-assembling peptide P11-4 and resin infiltration had a positive effect on WSLs but the findings should be interpreted cautiously.
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This review of the long-term efficacy of resin infiltration therapy for white sport lesions with regard to aesthetic appearance and long-term stability included 11 studies 9 of which were RCTs. The findings suggest a benefit but the amount of evidence is limited.
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Seven RCTs were included in this review of of micro-invasive interventions for non-cavitated proximal caries suggesting that resin infiltration is effective in arresting caries progression.
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9 RCTs were included in this review of resin infiltration for the clinical management of early non-cavitated proximal caries lesions. The findings indicate that resin infiltration when combined with oral hygiene measures was promising and more effective than oral hygiene measures alone.
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This review of micro-invasive treatments for proximal caries included 13 split-mouth RCTs. There was moderate quality evidence to support sealing in infiltration of early proximal caries compared with non-invasive treatments such as diet and bio-film management and topical fluorides.
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This review of treatments for post orthodontic white spot lesions included 20 studies examining a wide variety of approaches. Modest benefits were seen in addition to daily use of fluoride toothpaste and furhter high quality studies are needed to identify the best approaches.
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This review of resin infiltration for enamel development defects and WSLs included 11 studies (7 RCTs) of limited quality. They suggest it may be a feasible treatment option, but high quality studies are needed.
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Only 8 studies at high risk of bias were available for this review of treatments for post orthodontic white spot lesions (WSLs) . They provide little reliable evidence to support remineralising or camouflaging strategies to manage WSLs.
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8 trials involving a total of 365 patients were included in this Cochrane review of micro-invasive treatments for proximal caries. Micro-invasive treatment significantly reduced the odds of lesion progression compared with non-invasive treatment (e.g fluoride varnish) or oral hygiene advice (e.g to floss) OR=0.24, (95% CI; 0.14 to 0.41).
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