This review of the efficacy of fluoride-free nano-hydroxyapatite agents (nHA) to enhance remineralisation or hamper demineralisation of enamel caries included 10 small studies. 5 studies were in-vivo and 5 in-situ but they were of short duration with 7 being at high risk of bias so provide very low certainty evidence. Additional high quality well reported studies are needed to assess nHA.
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This review of molar-incisor hypomineralisation management only included 14 limited quality and mainly observations studies.For molars composites, preformed metal crowns or indirect restorations seem suitable but more high quality studies are needed.
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Only 8 studies at high risk of bias were available for this review of treatments for post orthodontic white spot lesions (WSLs) . They provide little reliable evidence to support remineralising or camouflaging strategies to manage WSLs.
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This review looked at topical fluoride for remineralising or arresting caries. 17 RCTs were included and overall remineralised early enamel caries using % fluoride varnish = 63.6 % (95% CI; 36.0 to 91.2 %) and 38% silver diamine fluoride had an overall proportion of arrested dentine caries = 65.9% (95% CI; 41.2 to 90.7 %).
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Dental caries remains a major public health problem. It has been demonstrated in in vitro studies that Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) has a remineralising effect on enamel lesions. The aim of this systematic review was to assess the long-term (>3 months) remineralizing effect of CPP-ACP on early caries lesions in vivo compared with placebo [read the full story…]
White spot lesions (WSLs) are a common adverse effect of orthodontic treatment. The incidence of these lesions is high with some estimates as high as 97%. The aim of this review was to assess the evidence regarding the effect of remineralizing agents on post-orthodontic WSLs and to evaluate which remineralizing agents are effective for the [read the full story…]
March sees another two protocols registered with the Cochrane Oral Health Group. The protocols are available on the Cochrane Library Parnell C, Gugnani N, Sherriff A, James P, Beirne PV. Non-fluoride topical remineralising agents containing calcium and/or phosphate for controlling dental caries (Protocol). Cochrane Database of Systematic Reviews 2012, Issue 3. Art. No.: CD009732. DOI: [read the full story…]
