Web-based guided self-help can prevent or delay major depression

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Ioana Cristea is impressed by a large German randomised controlled trial published yesterday in JAMA, which shows web-based guided self-help to be effective in preventing or delaying the onset of major depression.

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Mental health literacy: can it be taught to teenagers?

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Jasmin Wertz reports on a recent Canadian cluster RCT, which studies the impact of a mental health curriculum for high school students on knowledge and stigma.

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Collaborative care for depression: acceptable, effective and affordable

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Ben Hannigan writes his debut blog on the CADET cluster RCT, which investigates the clinical effectiveness and cost-effectiveness of collaborative care for depression in UK primary care.

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Mindfulness-based cognitive therapy cannot substitute maintenance antidepressants for preventing depression relapse

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Ioana Cristea takes a closer look at a recent non-inferiority RCT, which compares mindfulness-based cognitive therapy (MBCT) plus discontinued antidepressants versus MBCT and maintenance antidepressants.

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Long-term psychoanalytic psychotherapy for treatment-resistant depression

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Sarah McDonald presents the results of the Tavistock Adult Depression Study; a pragmatic RCT of long-term psychoanalytic psychotherapy for treatment-resistant depression.

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Nicotine patches, Varenicline and combination NRT: as good/bad as each other?

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Paul Christiansen considers the findings of a recent RCT, which evaluates the effects of nicotine patches versus varenicline versus combination nicotine replacement therapy on smoking cessation at 26 weeks.

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Cognitive therapies for depression in adults: let’s just stick to the facts

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Ioana Cristea reviews the NIHR-DC Highlight on cognitive therapies for depression, published online today, which summarises three NIHR-funded trials (REEACT, CoBalT and PREVENT) looking at cCBT, CBT and MBCT for depression in adults.

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Cognitive stimulation therapy for dementia

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Clarissa Giebel summarises a multicentre RCT that assesses the clinical effectiveness and cost-effectiveness of individual cognitive stimulation therapy for dementia.

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Aripiprazole for treatment-resistant depression in older adults

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Sarsha Wilson publishes her debut blog about a recent RCT on the efficacy, safety and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in later life.

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