Depot antipsychotics: If you pay me, you can keep injecting me


John Baker looks at the 2-year follow-up results of a cluster RCT on the effectiveness of financial incentives to improve adherence to maintenance treatment with depot antipsychotics.

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It’s good to talk: training psychiatrists to improve communication with patients


John Baker evaluates the recent TEMPO cluster RCT, which explores training to enhance psychiatrist communication with patients who live with psychosis.

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Specialist depression service may help people with persistent depression


Ben Hannigan reports on a recent RCT of the efficacy and cost-effectiveness of a specialist depression service versus usual specialist mental health care to manage persistent depression.

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Depression and coronary heart disease: reasons to remain UPBEAT-UK


Kirsten Lawson summarises the UPBEAT-UK programme of research into the relationship between coronary heart disease and depression and anxiety in primary care patients.

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Behavioural activation not inferior to CBT for depression: the COBRA RCT


Ioana Cristea appraises the recently published COBRA randomised controlled trial, which concludes that behavioural activation is non-inferior to cognitive behavioural therapy for depression, and may offer significant cost savings.

This blog also features a podcast interview with the lead author: Professor David Richards from Exeter University.

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Worried sick: cCBT and bibliotherapy for somatic symptom disorder and illness anxiety disorder


Suzanne Dash considers the findings of a recent RCT of exposure-based cognitive-behavioural therapy via the internet and as bibliotherapy for somatic symptom disorder and illness anxiety disorder.

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Have the EAGLES landed? Safety of varenicline, bupropion and NRT in smokers with and without mental illnesses


Paul Christiansen presents the results of the EAGLES RCT into the neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patches in smokers with and without psychiatric disorders.

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Internet-based problem-solving guided self-help for depression whilst waiting for therapy


Alastair Canaway summarises a trial of the clinical and cost-effectiveness of internet-based problem-solving guided self-help intervention, in comparison with enhanced usual care, for outpatients on a waiting list for face-to-face treatment for major depression.

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ITI-007 for schizophrenia


Murtada Alsaif summarises a recent 4-week long phase II randomised controlled trial of ITI-007 for the treatment of schizophrenia, which contains some positive results for this novel intervention.

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