Community treatment orders still don’t work at 36 months: OCTET trial follow up


Raphael Underwood presents the 3 year follow up of the OCTET trial of community treatment orders for people with psychosis, which finds no significant difference on readmission or disengagement for patients on CTOs compared to those discharged to voluntary status via Section 17 leave.

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Computerised CBT for depression is no better than usual GP care: the REEACT trial


Another debut blog today, this time from Suzanne Dash, who presents the results of the REEACT trial published last week in the BMJ. The study found limited uptake of computerised CBT by people with clinical depression and no benefit of free or commercially available cCBT packages over usual GP care.

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Collaboration, collaboration, collaboration


Kirsten Lawson explores the benefits of working across professional and therapeutic boundaries, highlighted beautifully by the recent COINCIDE RCT of collaborative care for patients with depression comorbid with diabetes or cardiovascular disease.

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Is cCBT doing it for the kids, but not the adults?


Karina Lovell appraises the first UK RCT of computerised cognitive behavioural therapy (cCBT) for depression in children and young people, which shows a clinically meaningful improvement in depression and anxiety.

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Integrated treatment for first episode psychosis: media hype versus reality


Alex Langford reflects on the media hype surrounding a new RCT of the NAVIGATE intervention; a comprehensive, multidisciplinary, team-based treatment approach for first episode psychosis.

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Placebo responding and µ-opioid brain functioning predict efficiency of antidepressants


Dan-Mikael Ellingsen explores the neurochemistry of placebo effects in major depression, as he reviews a recent study of the association between placebo-activated neural systems and antidepressant responses.

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The PACE Trial for chronic fatigue syndrome: choppy seas but a prosperous voyage


Simon Wessely responds to the huge amount of recent criticism that has surrounded the publication of a follow-up paper of the PACE trial into chronic fatigue syndrome. This extended blog presents the PACE trial and its main results, but also reminds us what makes a good RCT, as well as exploring how well PACE measures up.

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Early intervention in psychosis: how long is long enough?


Rachel Brand looks at a recent RCT which investigates the optimal duration of an early intervention in psychosis programme for young people in Hong Kong.

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Telemedicine psychotherapy for older veterans with depression


Lisa Burscheidt appraises an RCT of telemedicine psychotherapy for depression in older veterans, which establishes non-inferiority of telemedicine delivery versus same-room delivery of behavioural activation.

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