Antidepressant withdrawal or depression relapse? International guidelines on antidepressant discontinuation are unclear

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Adele Framer summarises a systematic review which finds that major guidelines on antidepressant discontinuation only give clinicians vague guidance on distinguishing withdrawal from relapse.

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Substance use is higher and more excessive in transgender people: evidence, limitations and gaps

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Ivan Ezquerra-Romano summarises a systematic review looking into the prevalence of substance use among transgender people compared to their cisgender counterparts.

Today we also announce the launch of a new survey that will help us understand alcohol use in UK transgender and non-binary people.

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Prescription drug misuse in women: US review inconclusive

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Rob Poole writes his debut elf blog on a recent systematic review of trends in prescription drug misuse among women, which finds a mixed and complex picture with few conclusive findings.

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The US opioid crisis: quantifying the impact

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Emma Wincup examines a recent US cross-sectional study that measures the burden of opioid-related mortality in the United States, which suggests that opioids (prescribed and illicit) could kill nearly half a million people across America over the next decade.

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Non-medical use of prescription drugs #NonMedicalDrugs

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Ian Hamilton and Julia Buxton from the University of York preview the #NonMedicalDrugs event that will take place in York on Friday 16th March 2018.

The meeting will bring together people who can offer personal and professional insights of the extent of the issue and how we can support people who develop problems.

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Off-label antidepressants: limited evidence to support their use

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John Baker reports on Canadian study looking at prescriptions of off-label antidepressants in primary care, which concludes that when antidepressants were used outside of their licence, there was usually not strong evidence supporting the respective indication.

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NICE one? Is NHS guidance on substance misuse fit for purpose?

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Ian Hamilton explains why the National Institute for Health and Care Excellence have missed a trick by not updating their 2007 guidance on psychosocial interventions for substance misuse.

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US policy on prescription drug abuse: tackling an unique and significant problem

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The fact that drug overdoses are the second largest cause of premature death from unintentional injuries in the US (for example, in 2010 there was 38,329 drug overdose deaths) is not a surprising statistic. What may surprise readers is that of these deaths 22,134 were attributed to prescription drugs. Indeed, almost one and a half [read the full story…]

Psychiatric drugs make up a bigger proportion of all prescription costs than they did a decade ago

Studies in which no placebo condition was included, resulted in a small but significant difference in favour of pharmacotherapy.

There continues to be a considerable amount of debate about the amount of psychiatric medication that is prescribed and how much it costs. Statistics from a number of countries have shown that many classes of drugs are being prescribed more and more, including antidepressants, antipsychotics and stimulants. Of course, as populations grow, people live longer [read the full story…]

Psychiatric drugs are as effective as other drugs, says new review of meta-analyses

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There’s an interesting review in the British Journal of Psychiatry this week, which compares the effectiveness of psychiatric drugs with those used to treat physical health problems. The headline from the review is that ‘psychiatric drugs are as effective as other drugs’. Professor Stefan Leucht who led the review team claims that: There is a [read the full story…]