This review of the effectiveness of sodium bicarbonate in the prevention and management of oral mucositis included 11 RCTs. The included studies were small, hetrogeneous and suggested little benefit from the use of sodium bicoarbonate mouthwashes.
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Conventional ice chip cryotherapy was compared with a novel intraoral cooling device in this multi-centre randomised controlled trail conducted in five Scandinavian centres.
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This review of the efficacy of oral cryotherapy in the prevention of chemotherapy-induced oral mucositis included 14 studies and a total of 1577 patients. The findings indicate that oral cryotherapy is effective in preventing oral mucositis in patients undergoing chemotherapy for the management of solid malignancies.
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Manas Dave takes a look at this review aiming to identify the potential risk factors associated with the development of oral mucositis in paediatric patients. While a range of risk factos are higlighted it is worth noting that 80-100% of all children having chemotherapy experience some degree of mucositis.
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This review assessing the effectiveness of intraoral stents in reducing toxicities in oral cavity induced by radiotherapy in head and neck region included 7 small studies. While the analysis suggests a beneficial effect from the use of intraoral stents the included studies only provide verylow certainty evidence so further high-quality RCTs are needed.
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Manas Dave takes a look at this review evaluating the prophylactic and therapeutic effects of low-level laser therapy (LLLT) in patients who might or have developed oral mucositis during chemotherapy or radiotherapy.
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This review of of the effects of oral supplementation on the prevention and/or treatment of oral mucositis in patients with cancer undergoing chemotherapy and/or radiotherapy included 12 RCTs and suggest that Zinc supplements may be beneficial.
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This Cochrane review of cytokines and growth factors for preventing oral mucositis in patients having cancer treatment included 35 RCTs finding keratinocyte growth factor beneficial in the prevention of oral mucositis .
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This review of chlorhexidine (CHX) for prevention & treatment of oral mucositis included 12 RCTs with 9 contribution to the meta-analysis. CHX was not significantly effective in preventing mucositis or reducing its severity.
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This review of the use of honey to educe the severity of radio/chemotherapy-induced oral mucositis identified 7 low quality RCTs that suggest that use of honey may reduce the severity of oral mucositis.
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