Study finds better oral hygiene improved oral lichen planus


This small randomised trial found improvements in quality of life for patients with oral lichen planus at both 4 weeks and 20 weeks following implementation of a structured oral hygiene instruction.

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Oral lichen planus: is topical tacrolimus better than clobetasol?


Ten small RCTs were included in this review. They suggest that topical tacrolimus is more efficacious than clobetasol for oral lichen planus.

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Oral potentially malignant disorders and impact on quality of life


14 studies were included in this review of the impact of oral potentially malignant disorders of the quality of life. However, they were mainly focused on oral lichen planus, so they provide little evidence for the impact of the wide range of OPMDs on the quality of life.

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Small study suggests that low-level laser therapy may have some benefit in treatment oral lichen planus


Oral Lichen Planus (OLP) is a common chronic immunological disease the treatment of which remains a challenge for clinicians.  Two Cochrane reviews  have recently been published regarding the treatment of OLP (Chang et al 2012 and Thongorasom et al 2011 ). The quality of evidence for treatments for OLP is weak, but topical steroids are [read the full story…]

Malignant transformation in patients with oral lichen planus


This cohort study of 327 oral lichen planus (OLP) patients; 229 women (70.0%) and 98 men (30.0%), was conducted using data from a cohort of caucasian patients from Italy with clinical and pathologic diagnosis of OLP, according to revised and modified World Health Organization diagnostic criteria. Follow-up of the patient cohort was started 6 months [read the full story…]

Malignant transformation rates in oral potentially malignant disorders


The aims of the study were to determine how frequently oral potentially malignant disorders (OPMDs) transform to cancer and to identify clinical and histological factors determining the rates of transformation. The study cohort  included 1357 patients with biopsy-confirmed OPMDs seen at Guy’s Hospital between 1990 and 1999 and followed up until 2005.  The patients’ details [read the full story…]

Treatments for Oral Lichen Planus


The aim of this Cochrane review was to assess the effectiveness and safety of interventions to treat symptomatic, biopsy-proven oral lichen planus (OLP). OLP is a common chronic autoimmune disease associated with cell-mediated immunological dysfunction. The prevalence has been reported as 1.27% and it is more frequently seen in women aged between 30 and 60 [read the full story…]