This review of the efficacy and safety of topical interventions used for recurrent aphthous stomatitis included 72 studies assessing 29 different interventions. Most of the interventions did not demonstrate significant differences with limitednumbers of studies for some interventions and overal limitations in the quality of the evidence.
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This review of the effectiveness of locally administered antibiotics in the treatment of peri-implantitis included 12 small studies 7 of which were RCTs. While the findings suggest a small additional benefit with antibiotic use however the clinical importance of this is debatable.
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In 2015 the American Dental Association published a Guideline on nonsurgical treatment of chronic periodontitis. This network meta-analysis re-analyses the included studies providing a complementary appraisal of the data.
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This new systematic review from the ADA includes 72 RCTs on nonsurgical treatment approaches for chronic periodontitis. The systematic review provides the basis for a new clinical practice guideline.
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