Work Capability Assessments linked with increase in suicides


Ian Cummins considers the findings of a recent longitudinal study that measures the impact that welfare reform and disability assessments have had on mental illness and rates of suicide.

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All in the mindfulness? Reflections on the Mindful Nation report


André Tomlin considers the recommendations for health service delivery and research from the recent Mindful Nation report.

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Computerised CBT for depression is no better than usual GP care: the REEACT trial


Another debut blog today, this time from Suzanne Dash, who presents the results of the REEACT trial published last week in the BMJ. The study found limited uptake of computerised CBT by people with clinical depression and no benefit of free or commercially available cCBT packages over usual GP care.

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Antidepressants vs placebo for depression: forget the gap


Ioana Cristea considers the possible causes responsible for the apparent narrowing of the drug-placebo gap, which over the last 30 years has seen estimates of depression symptom reduction from antidepressants fall from 70% to 30%.

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Collaboration, collaboration, collaboration


Kirsten Lawson explores the benefits of working across professional and therapeutic boundaries, highlighted beautifully by the recent COINCIDE RCT of collaborative care for patients with depression comorbid with diabetes or cardiovascular disease.

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Is cCBT doing it for the kids, but not the adults?


Karina Lovell appraises the first UK RCT of computerised cognitive behavioural therapy (cCBT) for depression in children and young people, which shows a clinically meaningful improvement in depression and anxiety.

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Should we recommend CBT for depression in people with learning disabilities?


Leen Vereenooghe summarises a systematic review of the use of CBT (cognitive behavioural therapy) to treat depression in people with learning disabilities.

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Placebo responding and µ-opioid brain functioning predict efficiency of antidepressants


Dan-Mikael Ellingsen explores the neurochemistry of placebo effects in major depression, as he reviews a recent study of the association between placebo-activated neural systems and antidepressant responses.

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Psychotherapies for depression and anxiety in dementia

The study highlighted a lack of evidence about what CMHT services work for older people.

Clarissa Giebel summarises a recent systematic review that investigates the effectiveness of various psychotherapies (CBT, interpersonal therapy, counselling) for depression and anxiety in people with dementia or mild cognitive impairment.

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