Root canal disinfection –sodium hypochlorite or chlorhexidine as an irrigant?

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This review only identified 5 small studies that provided insufficient evidence to compare outcomes using sodium hypochlorite and chlorhexidine for root canal disinfection. Additional high quality RCTs are required.

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Root canal treatment – no differences between single or multiple visit approaches

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This RCT found no differences between single and multiple visit root canal treatment outcomes at 18 months Success rates for single visit treatments were 88.9% compared with 87.4% for multiple visits

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Orthodontic retention – little high quality evidence to recommend any one approach to over another

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15 studies involving 1722 patients were included in this Cochrane review update on orthodontic retention. However, there was insufficient high quality evidence to make recommendations on retention procedures.

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Omega-3 fatty acids for depression: Cochrane find insufficient evidence to support use

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Lisa Burscheidt summarises a recent Cochrane systematic review of Omega-3 fatty acids for depression in adults, which finds a lack of evidence to determine the effects of n-3PUFAs as a treatment for major depressive disorder.

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Sealants or fluoride varnish for caries prevention?

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This Cochrane review update included 8 trials involving 1746 participants. Some low-quality evidence suggesting the superiority of resin-based fissure sealants over fluoride varnish applications was identified

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Medication for cognitive impairment in traumatic brain injury: little evidence to support its use

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Eleanor Kennedy summarises a recent Cochrane review of pharmacotherapy for chronic cognitive impairment in traumatic brain injury, which finds insufficient evidence to support its use.

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Lithium for schizophrenia: Cochrane find lack of evidence to support its use

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Raphael Underwood presents a new Cochrane review of lithium for schizophrenia, which assesses the use of lithium as a monotherapy and also in combination with antipsychotics.

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Oral cryotherapy reduces oral mucositis in patients receiving 5FU-based treatment for solid cancers

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This Cochrane review looked at cryotherapy (ice chips) for preventing oral mucositis in patients with cancer. 14 RCTS involving 1280 patients were included providing evidence that oral cryotherapy leads to large reductions in oral mucositis of all severities in adults receiving 5FU for solid cancers. However there was less confidence confident in the ability of oral cryotherapy to reduce oral mucositis in adults receiving high-dose melphalan before haematopoietic stem cell transplantation (HSCT).

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Preventing bleeding in patients with congenital bleeding disorders having dental surgery

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This Cochrane review only identified 2 RCTs involving a total of 59 patients that show a beneficial effect of systemically administered tranexamic acid and epsilon aminocaproic acid in preventing postoperative bleeding in people with haemophilia undergoing dental extraction.

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Crowns more effective than fillings for decay in primary molar teeth

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Five RCTs were included in this Cochrane review comparing crowns with fillings for the management of caries in primary molars. Moderate evidence found crowns reduced the risk of major failure or pain in the long term compared to fillings

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