Parasympathomimetic drugs for dry mouth after radiotherapy


The update of a 2007 Cochrane review of parasympathomimetic drugs for dry mouth after radiotherapy did not identify an new studies. The 3 RCTs identified in the previous version provide limited evidence to support the use of pilocarpine hydrochloride in the treatment of radiation-induced xerostomia.

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Tooth Mousse® for caries prevention – little evidence available

shutterstock_34500700 - caries sign

This review of Tooth Mousse® (casein phosphopeptide-amorphous calcium phosphate) for caries prevention only identified 12 studies (8 RCTs). Many were of short duration and exhibited a great deal of heterogeneity; while there is some suggestion of benefit, the quality of the evidence is very low.

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Reducing gagging during dental treatment – insufficient evidence for any intervention


This Cochrane review was only able to identify a single small RCTs of acupuncture to reduce gagging during dental treatment. This was insufficient to conclude any benefit. No evidence of other interventions was identified.

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Sedation or general anaesthesia for dental treatment in children


This update of a Cochrane review, first published in 2009, did not identify any RCTs comparing the efficiency of sedation versus general anaesthesia (GA) for the provision of a dental treatment.

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Fluoridated milk: low quality evidence of benefit


The updated Cochrane review only included 1 low quality RCT. A substantive reduction in decay for primary teeth was seen equivalent to a prevented fraction of 31% but further research is likely to have an important impact on this estimate.

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Antidepressants for depression in cancer: Cochrane review highlights lack of evidence

Female cancer patient

Kirsten Lawson reports on a recent Cochrane systematic review, which highlights a lack of high quality trials about the efficacy and safety of antidepressants for depression in cancer.

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Exercise therapy for chronic fatigue syndrome


In this blog, Tracey Howe looks at a Cochrane systematic review, examining the effects of exercise therapy for patients with Chronic Fatigue Syndrome.

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Medication for self-harm: new Cochrane review finds very limited evidence to support its use


Dochka Hristova reports on a new Cochrane review of pharmacological interventions for self-harm in adults, which looks at the treatment effect on repetition of self-harm of antidepressants, antipsychotics, mood stabilisers and dietary supplements.

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Dry socket prevention: eugenol dressing or chlorhexidine gel?


This trial compared eugenol dressing or chlorhexidine gel for dry socket prevention against no intervention. Both agents reduced the incidence of dry socket but the reduction was greater with eugenol.

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Treatments for delusional disorder


Andrew Shepherd summarises a Cochrane systematic review of treatments for delusional disorder, which finds only 1 small RCT looking at treating the condition with medication or psychotherapy compared to placebo.

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