Treatment for depression in traumatic brain injury: Cochrane find no evidence for non-pharmacological interventions

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Eleanor Kennedy summarises a recent Cochrane systematic review, which finds no evidence to support the use of non-pharmacological interventions for depression in traumatic brain injury.

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Oro-antral communications – insufficient evidence for treatment approaches

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This Cochrane review of interventions for hte management of or-antral communications only identified 1 small trial which provides insufficient evidence for management of oro-antral communications.

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Infraorbital nerve block for postoperative pain following cleft lip repair in children

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This Cochrane review of Infraorbital nerve block for postoperative pain after cleft lip repair includes 8 trials providing low to very low quality evidence that infraorbital nerve block with lignocaine or bupivacaine may reduce postoperative pain more than placebo

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Crisis intervention for severe mental illness: Cochrane call for more evidence

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John Baker is struck by the lack of evidence for crisis intervention for people with severe mental illness, highlighted by a recently updated Cochrane systematic review.

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Adhesively bonded amalgams – insufficient evidence of better performance

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This Cochrane review update only identified 1 RCT assessing the difference in survival between bonded and non-bonded amalgam restorations providing insufficient evidence to support or refute a difference.

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Methylphenidate for ADHD: have Cochrane got it wrong this time?

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Chris Hollis appraises a recent Cochrane systematic review, which casts doubt over the quality of trial evidence and the clinical effectiveness of Methylphenidate for ADHD.

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Bisphosphonate-related osteonecrosis of the jaw treatments– little evidence available

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This Cochrane review of bisphosphonate related osteonecrosis of the jaw only identified one small RCT. The trial compared the use of hyperbaric oxygen (HBO) as an adjunct to standard care. While it suggested a benefit for HBO it was under powered and at high riisk of bias

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Statins for dementia prevention: well-tolerated, but Cochrane highlight lack of evidence

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Rosalyn Nelson summarises a recently updated Cochrane systematic review of statins for dementia prevention, which finds no evidence to support their use.

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Periodontal disease and glycaemic control in diabetics

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11 systematic reviews were included in this overview of review of periodontal disease and glycaemic control in diabetics. The primary studies that underlying these systematic reviews have important limitations. Therefore larger higher quality studies are needed.

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Little evidence for antibiotic use in irreversible pulpitis

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This is the latest update of this Cochrane review of the effectiveness of antibiotics for irreversible pulpitis. Only 1 small RCTs is available which provides insufficient evidence to determine whether antibiotics reduce pain or not compared to not having antibiotics

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