CBT plus medication for treatment-resistant depression: the CoBalT RCT long-term follow-up

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Sarah McDonald considers the findings of the CoBalT RCT long-term follow-up, which finds that CBT plus antidepressants are clinically and cost effective for treatment-resistant depression in primary care.

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Top mental health blogs in 2015

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André Tomlin presents his review of 2015, the year when the Mental Elf came of age. He highlights our top mental health blogs, showcases the #WeCATS and #ElfCampfire activities and explains how the new National Elf Service website can help you engage more with relevant and reliable research.

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Work Capability Assessments linked with increase in suicides

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Ian Cummins considers the findings of a recent longitudinal study that measures the impact that welfare reform and disability assessments have had on mental illness and rates of suicide.

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Antidepressants vs placebo for depression: forget the gap

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Ioana Cristea considers the possible causes responsible for the apparent narrowing of the drug-placebo gap, which over the last 30 years has seen estimates of depression symptom reduction from antidepressants fall from 70% to 30%.

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Should we recommend CBT for depression in people with learning disabilities?

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Leen Vereenooghe summarises a systematic review of the use of CBT (cognitive behavioural therapy) to treat depression in people with learning disabilities.

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Placebo responding and µ-opioid brain functioning predict efficiency of antidepressants

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Dan-Mikael Ellingsen explores the neurochemistry of placebo effects in major depression, as he reviews a recent study of the association between placebo-activated neural systems and antidepressant responses.

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Antidepressant meta-analyses: big business and bias

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Alex Langford reflects on the findings of a recent study that looks at 185 meta-analyses of antidepressants. It finds that industry involvement in research can lead to biased studies that under-report negative aspects of antidepressants for depression.

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What impact are psychotropic drugs having on our physical health?

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John Baker summarises the findings of a recent review of people with schizophrenia, bipolar disorder and depression. The study looks at the adverse effects on physical health of psychotropic drugs (antipsychotics, antidepressants and mood stabilisers).

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No link between SSRI use and violent crime in over 25s

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Sarah McDonald considers the implications of a recent cohort study of SSRI use and violent crime, which suffered from the usual headline grabbing media coverage, so typical of research about young people, violence, crime, drugs and mental health.

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Antidepressants for depression: new BAP guidance

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Helge Hasselmann summarises the recently published evidence-based guidance on antidepressants for depression published by the British Association for Psychopharmacology.

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