Work Capability Assessments linked with increase in suicides


Ian Cummins considers the findings of a recent longitudinal study that measures the impact that welfare reform and disability assessments have had on mental illness and rates of suicide.

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Antidepressants vs placebo for depression: forget the gap


Ioana Cristea considers the possible causes responsible for the apparent narrowing of the drug-placebo gap, which over the last 30 years has seen estimates of depression symptom reduction from antidepressants fall from 70% to 30%.

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Should we recommend CBT for depression in people with learning disabilities?


Leen Vereenooghe summarises a systematic review of the use of CBT (cognitive behavioural therapy) to treat depression in people with learning disabilities.

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Placebo responding and µ-opioid brain functioning predict efficiency of antidepressants


Dan-Mikael Ellingsen explores the neurochemistry of placebo effects in major depression, as he reviews a recent study of the association between placebo-activated neural systems and antidepressant responses.

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Antidepressant meta-analyses: big business and bias


Alex Langford reflects on the findings of a recent study that looks at 185 meta-analyses of antidepressants. It finds that industry involvement in research can lead to biased studies that under-report negative aspects of antidepressants for depression.

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What impact are psychotropic drugs having on our physical health?


John Baker summarises the findings of a recent review of people with schizophrenia, bipolar disorder and depression. The study looks at the adverse effects on physical health of psychotropic drugs (antipsychotics, antidepressants and mood stabilisers).

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No link between SSRI use and violent crime in over 25s


Sarah McDonald considers the implications of a recent cohort study of SSRI use and violent crime, which suffered from the usual headline grabbing media coverage, so typical of research about young people, violence, crime, drugs and mental health.

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Antidepressants for depression: new BAP guidance


Helge Hasselmann summarises the recently published evidence-based guidance on antidepressants for depression published by the British Association for Psychopharmacology.

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Combined methylphenidate and citalopram may help older people with depression recover faster

Depressed older man

Lisa Burscheidt summarises a recent randomised controlled trial of combined methylphenidate and citalopram for depression in older people, which presents promising but limited findings.

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Antidepressants for depression in cancer: Cochrane review highlights lack of evidence

Female cancer patient

Kirsten Lawson reports on a recent Cochrane systematic review, which highlights a lack of high quality trials about the efficacy and safety of antidepressants for depression in cancer.

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