The aim of this trial was to assess the efficacy of a topical gel with triester glycerol oxide for treating ulcerations related to new complete dentures was studied and compared with a placebo gel.

Fifty edentulous patients who received new maxillary and mandibular complete dentures were enrolled in this double-blind clinical study. Twenty-five patients received topical gel with triester glycerol oxide (TGO), and 25 patients received topical gel without TGO. They  were recalled 1, 3 and 7 days after denture placement, pain and discomfort was assessed at each visit. At 7 days healing of ulceration was also graded by a clinician, patients graded the gel’s taste, smell and ease of use.

They found,no statistically significant difference in ulcer healing (p > 0.05), ratings of smell, taste and ease of use (p > 0.05) or pain and discomfort scores (p > 0.05). However, within-group differences were observed in pain and discomfort scores between follow-up sessions (p = 0.01 for all comparisons).

They concluded that

Clinically, TGO gel is not effective in the treatment of mucosal injuries occurring following placement of complete dentures.

Geckili  O. Bektas-Kayhan K, Eren  P, Bilgin T, Unur M. The efficacy of a topical gel with triester glycerol oxide in denture-related mucosal injuries. Gerodontology.  Article first published online: 24 Aug 2011  DOI: 10.1111/j.1741-2358.2011.00549.x