This study was a nested case-control study within the Oslo Study, (a cohort study of the prevention and epidemiology of cardiovascular diseases). The aim was to explore whether dental extractions are associated with myocardial infarction (MI).
The sample consisted of men with a self-reported history of MI as cases (n = 548) and controls (n = 625) who were selected randomly by 5-year strata to match the age distribution of cases. Reasons for extraction (self-reported) were recorded as periodontal infections (marginal periodontitis) or apical infection of a single tooth, and these were grouped as infection due to extractions. Extractions due to trauma or other causes were grouped as non-infection extractions.
They found that more men with a history of MI had extracted teeth than controls (92.7% versus 88.6%; P = 0.020). The prospective logistic regression analysis predicting nonfatal MI showed strength of association between infection extraction, no extraction, or non-infection extractions combined [odds ratio (OR) = 1.64; 95% confidence interval (CI): 1.24, 2.16] in adjusted analysis and crude analysis (OR = 1.73; 95% CI: 1.34, 2.23). Adjustment was made for known risk factors for MI and periodontitis in 1972 ⁄73, such as systolic blood pressure, smoking, total cholesterol, BMI, and education recorded in the 2000 screening.
Extractions due to dental infections were associated with nonfatal MI in elderly men.
Håheim LL, Olsen I, Rønningen KS. Association between tooth extraction due to infection and myocardial infarction. Community Dent Oral Epidemiol. 2011 May 9.doi: 10.1111/j.1600-0528.2011.00616.x. [Epub ahead of print] PubMed PMID: 21557755.