This study looked at the behavioural phenotype of people with Prader-Willi syndrome and the relationship between behavioural problems and age groups, genetic subtypes and BMI categories.

It found statistically significant differences between age groups and between genetic subtypes but none in different BMI categories.

The authors suggest that special attention should be paid to behavioural problems as part of general management of adults with PWS, and suggest the need for longitudinal studies to gain more insight into the natural history and course of behavioural problems in adults and older people with PWS over the long term.

Behavioral phenotype in adults with Prader–Willi syndrome, Sinnema M et al, in Research in Developmental Disabilities, 32, 2, 604-612